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Clinical Epidemiology Research Center (CERC)

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Selected CERC Publications

The following is a list of selected recent publications by CSP Investigators at the Clinical Epidemiology Research Center. The overall portfolio of projects and articles reflects the Center's broad diversity of investigators, as well as active collaborations with other researchers both within and beyond the Center.

  1. Lei Yan, David Bui, Yuli Li, et al. Identifying Veterans Who Benefit From Nirmatrelvir-Ritonavir: A Target Trial Emulation. Clinical Infectious Diseases, Jun 12 2024; doi: 10.1093/cid/ciae202. Link: Identifying Veterans Who Benefit From Nirmatrelvir-Ritonavir: A Target Trial Emulation | Clinical Infectious Diseases | Oxford Academic (oup.com)
  2. Li G, Gerlovin H, Figueroa Muñiz MJ, et al. Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. Epidemiology. 2024 Mar 1;35(2):137-149. doi: 10.1097/EDE.0000000000001709. Epub 2023 Dec 18. PMID: 38109485; PMCID: PMC11022682. Link: Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness - PubMed (nih.gov)
  3. Harrington, K.M.; Quaden, R.; Steele, L. et al. The Million Veteran Program 1990–1991 Gulf War Era Survey: An Evaluation of Veteran Response, Characteristics, and Representativeness of the Gulf War Era Veteran Population. Int. J. Environ. Res. Public Health 2024, 21, 72; doi.org/10.3390/ijerph21010072. Link: The Million Veteran Program 1990-1991 Gulf War Era Survey: An Evaluation of Veteran Response, Characteristics, and Representativeness of the Gulf War Era Veteran Population - PubMed (nih.gov)
  4. Gulanski BI, Goulet JL, Radhakrishnan K, et al. Metformin prescription for U.S. veterans with prediabetes, 2010-2019. J Investig Med. 2024 Jan;72(1):139-150. doi: 10.1177/10815589231201141. Epub 2023 Nov 20. PMID: 37668313. Link: Metformin prescription for U.S. veterans with prediabetes, 2010-2019 - PubMed (nih.gov)
  5. Zhou H, Kember RL, Deak JD, et al. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nat Med. 2023 Dec;29(12):3184-3192. doi: 10.1038/s41591-023-02653-5. Epub 2023 Dec 7. PMID: 38062264; PMCID: PMC10719093. Link” Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals - PubMed (nih.gov)
  6. Ioannou GN, Berry K, Rajeevan N, et al. Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation. Ann Intern Med. 2023 Nov;176(11):1486-1497. doi: 10.7326/M23-1394. Epub 2023 Oct 31. PMID: 37903369; PMCID: PMC10620954. Link: Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among U.S. Veterans (acpjournals.org)
  7. Austin-Zimmerman I, Levey DF, Giannakopoulou O, et al. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. Nat Commun. 2023 Sep 28;14(1):6059. doi: 10.1038/s41467-023-41249-y. PMID: 37770476; PMCID: PMC10539313. Link: Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration - PubMed (nih.gov)
  8. Wendt, F.R., Pathak, G.A., Vahey, J. et al. Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. Hum Genomics 17, 46 (2023); doi:10.1186/s40246-023-00487-3. Link: Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program - PubMed (nih.gov)
  9. Colbert, S.M.C., Wendt, F.R., Pathak, G.A. et al. Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts. AJHG 2023, 110, 6; doi: 10.1016/j.ajhg.2023.04.007. Link: Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts - PubMed (nih.gov)
  10. Vasterling JJ, Franz MR, Lee LO, et al. Early predictors of chronic posttraumatic stress disorder symptom trajectories in U.S. Army soldiers deployed to the Iraq war zone. J Trauma Stress. 2023 Oct;36(5):955-967. doi: 10.1002/jts.22964. Epub 2023 Aug 22. PMID: 37608526. Link: Early predictors of chronic posttraumatic stress disorder symptom trajectories in U.S. Army soldiers deployed to the Iraq war zone - PubMed (nih.gov)
  11. Austin-Zimmerman I, Levey DF, Giannakopoulou O, et al. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. Nat Commun. 2023 Sep 28;14(1):6059. doi: 10.1038/s41467-023-41249-y. PMID: 37770476; PMCID: PMC10539313. Link: Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration - PubMed (nih.gov)
  12. Yan L, Streja E, Li Y, et al. Anti-SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Netw Open. 2023 Aug 1;6(8):e2331249. doi: 10.1001/jamanetworkopen.2023.31249. Link: Anti-SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023 - PubMed (nih.gov)
  13. Bajema KL, Berry K, Streja E, et al. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Ann Intern Med. Jun 6 2023; doi:10.7326/m22-3565. Link: Effectiveness of COVID-19 Treatment With Nirmatrelvir-Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes - PubMed (nih.gov)
  14. Duong LM, Nono Djotsa ABS, Vahey J, et al. Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis. Int J Environ Res Public Health. 2022 Dec 24;20(1):258. doi: 10.3390/ijerph20010258. PMID: 36612580; PMCID: PMC9819371.Link: Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis - PubMed (nih.gov)
  15. Bajema KL, Wang XQ, Hynes DM, et al. Early Adoption of Anti-SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022. JAMA Netw Open. 2022 Nov 1;5(11):e2241434. doi: 10.1001/jamanetworkopen.2022.41434. PMID: 36367727; PMCID: PMC9652752. Link: Early Adoption of Anti-SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022 - PubMed (nih.gov)
  16. Watanabe K, Jansen PR, Savage JE, Nandakumar P, et al. Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nat Genet. 2022 Aug;54(8):1125-1132. doi: 10.1038/s41588-022-01124-w. Epub 2022 Jul 14. PMID: 35835914. Link: Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways - PubMed (nih.gov)
  17. Lee KM, Heberer K, Gao A, et al. A Population-Level Analysis of the Protective Effects of Androgen Deprivation Therapy Against COVID-19 Disease Incidence and Severity. Front Med (Lausanne). 2022 May 4;9:774773. doi: 10.3389/fmed.2022.774773. PMID: 35602518; PMCID: PMC9115469. Link: A Population-Level Analysis of the Protective Effects of Androgen Deprivation Therapy Against COVID-19 Disease Incidence and Severity - PubMed (nih.gov)
  18. Radhakrishnan, K., Hauser, E.R., Polimanti, R., et al. Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006. Brain Sci. 2021, 11, 845; doi: 10.3390/brainsci11070845. Link: Brain Sciences | Free Full-Text | Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006 (mdpi.com)
  19. Harvey PD, Bigdeli TB, Fanous AH, et al. A Study of Serious Mental Illness in Veterans as a Pathway to personalized medicine in Schizophrenia and Bipolar Illness. Pers Med Psychiatry. 2021 Jul;27-28:10.1016/j.pmip.2021.100078. doi: 10.1016/j.pmip.2021.100078. PMID: 34222732; PMCID: PMC8247126. Link: Cooperative Studies Program (CSP) #572: A Study of Serious Mental Illness in Veterans as a Pathway to personalized medicine in Schizophrenia and Bipolar Illness - PubMed (nih.gov)
  20. Levey DF, Stein MB, Wendt FR, et al. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nat Neurosci. 2021 Jul;24(7):954-963. doi: 10.1038/s41593-021-00860-2. Epub 2021 May 27. PMID: 34045744; PMCID: PMC8404304. Link: Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions - PubMed (nih.gov)
  21. Jackson CE, Ciarleglio MM, Aslan M, et al. Associations Among Increases in Posttraumatic Stress Symptoms, Neurocognitive Performance, and Long-Term Functional Outcomes in U.S. Iraq War Veterans. J Trauma Stress. 2021 Jun;34(3):628-640. doi: 10.1002/jts.22663. Epub 2021 Mar 2. PMID: 33650202. Link: Associations Among Increases in Posttraumatic Stress Symptoms, Neurocognitive Performance, and Long-Term Functional Outcomes in U.S. Iraq War Veterans - PubMed (nih.gov)
  22. Stein MB, Levey DF, Cheng Z, et al. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nat Genet. 2021 Feb;53(2):174-184. doi: 10.1038/s41588-020-00767-x. Epub 2021 Jan 28. PMID: 33510476; PMCID: PMC7972521. Link: Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program - PubMed (nih.gov)
  23. Hauser RG, Bhargava A, Talmage R, et al. Data Object Exchange (DOEx) as a Method to Facilitate Intraorganizational Collaboration by Managed Data Sharing: Viewpoint. JMIR Med Inform. 2020 Oct 27;8(10):e19267. doi: 10.2196/19267. PMID: 33107829; PMCID: PMC7655462. Link: Data Object Exchange (DOEx) as a Method to Facilitate Intraorganizational Collaboration by Managed Data Sharing: Viewpoint - PubMed (nih.gov)
  24. Bigdeli T, Fanous A, Rajeevan N, Sayward F, et al. GENOME-WIDE ASSOCIATION STUDIES OF SCHIZOPHRENIA AND BIPOLAR DISORDER IN A DIVERSE COHORT OF US VETERANS. Schizophr Bull. 2020 May;46(Suppl 1):S103. doi: 10.1093/schbul/sbaa031.239. Epub 2020 May 18. PMCID: PMC7234483. Link: S173. GENOME-WIDE ASSOCIATION STUDIES OF SCHIZOPHRENIA AND BIPOLAR DISORDER IN A DIVERSE COHORT OF US VETERANS - PMC (nih.gov)
  25. Vasterling JJ, Aslan M, Proctor SP, et al. Long-term negative emotional outcomes of warzone TBI. Clin Neuropsychol. 2020 Aug;34(6):1088-1104. doi: 10.1080/13854046.2020.1749935. Epub 2020 Apr 17. PMID: 32301397. Link: Long-term negative emotional outcomes of warzone TBI - PubMed (nih.gov)
  26. Harvey PD, Sun N, Bigdeli TB, et al. Genome-wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder. Am J Med Genet Part B. 2020; 183B: 181–194. https://doi.org/10.1002/ajmg.b.32775. Link: Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder - Harvey - 2020 - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - Wiley Online Library
  27. Bigdeli T, Fanous A, Rajeevan N, et al. Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. Schizophr Bull. 2020 May;46(Suppl 1):S103. doi: 10.1093/schbul/sbaa031.239. Epub 2020 May 18. PMCID: PMC7234483. Link: Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans - PubMed (nih.gov)
  28. Levey DF, Gelernter J, Polimanti R, et al. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. Am J Psychiatry. 2020 Mar 1;177(3):223-232. doi: 10.1176/appi.ajp.2019.19030256. Epub 2020 Jan 7. PMID: 31906708; PMCID: PMC7869502. Link: Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program - PubMed (nih.gov)
  29. Gelernter J, Sun N, Polimanti R, et al. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biol Psychiatry. 2019 Sep 1;86(5):365-376. doi: 10.1016/j.biopsych.2019.03.984. Epub 2019 Apr 8. PMID: 31151762; PMCID: PMC6919570. Link: Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci - PubMed (nih.gov)
  30. Gelernter J, Sun N, Polimanti R, et al. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nat Neurosci. 2019 Sep;22(9):1394-1401. doi: 10.1038/s41593-019-0447-7. Epub 2019 Jul 29. PMID: 31358989; PMCID: PMC6953633. Link: Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans - PubMed (nih.gov)
  31. Stein MB, Levey DF, Polimanti R, et al. Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample European Neuropsychopharmacology. 29. S43. 10.1016/j.euroneuro.2019.07.085. Link: GENOMIC CHARACTERIZATION OF POSTTRAUMATIC STRESS DISORDER IN A LARGE (N) MULTI-POPULATION U.S. MILITARY VETERAN SAMPLE (researchgate.net)
  32. Harrington KM, Quaden R, Stein MB, et al. Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans. J Trauma Stress. 2019 Apr;32(2):226-237. doi: 10.1002/jts.22399. PMID: 31009556; PMCID: PMC6699164. Link: Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans - PubMed (nih.gov)
  33. Radhakrishnan K, Aslan M, Harrington KM, et al. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B. Int J Methods Psychiatr Res. 2019 Mar;28(1):e1767. doi: 10.1002/mpr.1767. Epub 2019 Feb 14. Erratum in: Int J Methods Psychiatr Res. 2019 Dec;28(4):e1783. doi: 10.1002/mpr.1783. PMID: 30767326; PMCID: PMC6877159. Link: Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B - PubMed (nih.gov)
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